In most situations, not really! Dirty dishes in the sink, toys in the living room, clothes on the floor are part of daily life for most of us. Appraisers are trained to look past these types of personal property. Their focus is on the permanent fixtures such as walls, floors, cabinets, etc..
If the appraisal is being completed for a lending transaction, keep in mind that photos of the interior will typically be included within the appraisal report provided to the bank or mortgage company. So, it may be a good idea to tuck away anything you wouldn’t want showing up in a picture. 
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In short, prepare your property the way that makes you feel comfortable but don’t add more stress to your life trying to make sure your house is “magazine” ready just for the appraiser’s sake!